Work

Comparison of Cardiac Output Measurement Techniques: Thermodilution Versus Biventricular Pressure-Volume Loop Recordings in Pigs

Year: 2025

Type: article

Abstract: BACKGROUND: Cardiac output (CO) measurement is crucial in cardiovascular research. Pressure-volume (PV) loop recordings provide detailed information on cardiac function, including CO. This study aimed to compare CO measurements obtained from biventricular PV loop recordings with thermodilution (TD) as a reference method in pigs. METHOD: The TD-CO was measured by right heart catheterisation. The PV-derived CO was obtained from both ventricles simultaneously, both during ongoing ventilation and in transient apnoea. Data were compared using the Bland-Altman method. The percentage error (PE%) and linear regression were calculated between the TD-CO and PV-derived CO. RESULTS: Simultaneous CO measurements from 43 pigs were analysed. Compared to thermodilution, the lowest bias was found in PV-derived CO from the left ventricle during ongoing ventilation (0.02 L/min, 95% confidence interval [0.2-0.3]) with a PE% of 30% during ongoing ventilation. The highest bias was found in PV-derived CO from the right ventricle during ongoing ventilation (0.9 L/min, 95% CI [0.5-1.3]) with a PE% of 67% during ongoing ventilation. CONCLUSIONS: PV-derived CO from the left ventricle showed very good agreement with TD-CO, with minimal bias, while PV-CO measurements from the right ventricle showed higher inaccuracy, likely due to anatomical differences between the ventricles.

Source: Heart Lung and Circulation

DOI: 10.1016/j.hlc.2025.05.080

Authors: Simone Juel Dragsbaek, Mathilde Emilie Kirk, Cecilie Dahl Baltsen, Asger Andersen, Mads Dam Lyhne

Institutions: Aarhus University, Aarhus University Hospital

Language: English

Topic: Hemodynamic Monitoring and Therapy

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,260