Work

Targeting AXL can effectively overcome c-Met-induced therapeutic resistance in renal cancer and promote tumor cell death through increased oxidative stress

Year: 2025

Type: article

Source: Cancer Letters

DOI: 10.1016/j.canlet.2025.217984

Authors: Akash Sabarwal, Marc Machaalani, Laxminarayan Rawat, Johannes Wedel, Saba Tabasum, Yuzuru Sasamoto, Florian Buerger, Josie Ascione, Marc Eid, Karl Semaan, Eddy Saad, Yifan Yang, Dongwon Lee, F. Stephen Hodi, Matthew L. Freedman, Gwo-Shu Mary Lee, Murugabaskar Balan, Toni K. Choueiri, Soumitro Pal

Institutions: Boston Children's Hospital, Harvard University, Dana-Farber Cancer Institute, Boston University, Brigham and Women's Hospital, University Medical Center Hamburg-Eppendorf, Dana-Farber/Harvard Cancer Center

Language: English

Topic: Renal cell carcinoma treatment

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: U.S. Department of Defense, Dana Foundation, National Cancer Coalition, American Society of Nephrology, Harvard Medical School, Dana-Farber Cancer Institute, Exelixis, Deutsche Forschungsgemeinschaft, Else Kröner-Fresenius-Stiftung, National Institutes of Health, National Cancer Institute, Medical Research Foundation

Awards: G1273380608, G1596961289, Identifizierung und funktionelle Charakterisierung monogenetischer Ursachen des steroidresistenten nephrotischen Syndroms und der fokalsegmentalen Glomerulosklerose., FUNCTIONALLY CHARACTERIZING THE NONCODING GENOME OF METASTATIC PROSTATE CANCER TO IDENTIFY THERAPEUTIC VULNERABILITIES., TRANSCRIPTION FACTOR ANALYSIS OF SLE...NEW GRANT, SIGNED 9/6/2019, EFFECTIVE, 9/15/2019, DISTRIBUTED 9/11/2019, FAADC 9/11/2019, G3037710727, G379534949, G4561983161, G459566464, G584760423, G6461959565, UTILIZING CELL-FREE METHYLOMES TO INFORM CLINICAL SCENARIOS IN RENAL CELL CARCINOMA., G9000124221

OpenAlex ID: W4413276175

FWCI: 3.523

Cites: 89

Cited by: 6

Related to: 10