Work

Ultrasonic Selective Opening of Microcavities for Drug Delivery Microimplants

Year: 2025

Type: article

Abstract: We present a fully passive, ultraminiaturized drug delivery microchip that enables wireless, on-demand release via ultrasonic actuation - a mechanism not previously demonstrated in implantable drug delivery systems. By eliminating the need for integrated power and control components, the device achieves sub-millimeter dimensions ($\times 0.5$mm$\times 1$mm), enabling minimally invasive implantation in sensitive or hard-to-reach tissues. The system relies on ultrathin metallic membranes ($\mu $m wide,$2~\mu $g of powder payload from individual microcavities in response to specific frequencies (360/420/580kHz), with membrane rupture occurring inin vivoconditions at ultrasonic intensities within clinically safe limits (2). This platform represents a significant step toward precise, programmable drug delivery in anatomically constrained or delicate regions.[2025-0104]

Source: Journal of Microelectromechanical Systems

DOI: 10.1109/jmems.2025.3597789

Authors: Theocharis Nikiforos Iordanidis, Argyris Spyrou, Göran Stemme, Niclas Roxhed

Institution: KTH Royal Institute of Technology

Language: English

Topic: Advanced MEMS and NEMS Technologies

Subfield: Electrical and Electronic Engineering

Field: Engineering

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $2,645