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Cardiomyocyte-specific LARP6 overexpression prevents angiotensin II-induced myocardial dysfunction and interstitial fibrosis

Year: 2025
Type: article
Abstract: LARP6 is a novel multifunctional RNA-binding protein whose role in the heart is poorly understood. Transgenic overexpression of LARP6 in cardiomyocytes caused mild cardiac fibrosis under basal conditions with no impact on cardiac function but, unexpectedly, blunted angiotensin-II-induced cardiac fibrosis and dysfunction. This protective effect of LARP6 overexpression was associated with significant shifts in the cardiac transcriptome alongside blunted fibroblast activation and cardiomyocyte apoptosis under hypertension conditions, highlighting LARP6 as a novel therapeutic target.
DOI: 10.1152/ajpheart.00196.2025
Authors: Jacob J. Russell, Tadashi Yoshida, Lixin Ma, Li Lee, Daniel J. Davis, Laurel A. Grisanti, Margot Ruff, Chastidy A. Bailey, Shawn B. Bender, Bysani Chandrasekar
Language: English
Field: Medicine
Open Access status: hybrid
Awards: Mineralocorticoid receptor-dependent coronary vascular dysfunction in obesity, G193469588, G1995786595, G2089850200, G6583187062, G7902671886, G9000179291, RECK regulation of NASH and fibrosis
OpenAlex ID: W4413278962
FWCI: 1.886
Cites: 59
Cited by: 3
Related to: 10