Work

Bioinspired Hierarchical Porous Tricalcium Phosphate Scaffold Prepared via Freeze Casting Combined with Material Jetting Templating

Year: 2025

Type: article

Abstract: Recapitulating the in vivo microenvironments of damaged tissues through modulation of the physicochemical properties of scaffolds can enhance cell proliferation and differentiation. However, it is often a technical challenge to fully mimic the hierarchical structure of the target tissues. Inspired by hierarchical natural bone, we developed, for the first time, tricalcium phosphate scaffolds with four-level hierarchical structures (FH-TCP) across macro- to nanoscales, via freeze casting combined with material jetting templating. The mechanical property of the FH-TCP scaffolds can be tailored to be close to the cancellous bone (0.5 ~ 3.5 MPa). In addition, the better cell viability of FH-TCP demonstrates great potential for practical applications.

Source: Journal of Materials Engineering and Performance

DOI: 10.1007/s11665-025-11774-6

Authors: Jingyu Liu, Sepanta Hosseinpour, Chun Xu, Tony Wang, Cheng Yan

Institutions: Taiyuan University of Technology, The University of Queensland, The University of Sydney, Queensland University of Technology

Language: English

Topic: Bone Tissue Engineering Materials

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,190