Work

Extracellular serine proteases activate amiloride-insensitive ENaC channels and decrease migration and invasion ability of human leukemia cell lines

Year: 2025

Type: article

Abstract: In clinical practice, leukemia cells can exhibit drug resistance to standard treatments; therefore, identification of new therapeutic strategies is needed to prevent leukemia relapse. Here, it was shown for the first time that serine proteases α-chymotrypsin and plasmin significantly inhibit the motility of leukemia cells that express functionally active ENaCs. Thus, extracellular serine proteases as regulators of Na+ handling via ENaC channels could be considered as new suppressors of leukemia cell locomotion.

Source: American Journal of Physiology-Cell Physiology

DOI: 10.1152/ajpcell.00584.2024

Authors: Daria V. Lysikova, Polina I. Kirillova, Irina O. Vassilieva, Maxim L. Bychkov, Vladislav I. Chubinskiy-Nadezhdin, Anastasia V. Sudarikova

Institutions: Russian Academy of Sciences, Institute of Cytology, City Clinical Hospital No 31, Institute of Bioorganic Chemistry

Language: English

Topic: Ion channel regulation and function

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funder: Russian Science Foundation