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A Novel Monoterpenoid Derivative Isolated from Chloranthus serratus Roots with Anti-inflammatory Activity

Year: 2025

Type: article

Abstract: Eight compounds were isolated from the 95% ethanol extract of Chloranthus serratus roots, including two monoterpenoid derivatives (1, 2), one pimarane-type diterpenoid (3), and five labdane-type diterpenoids (4-8). Compound 1 was identified as a previously undescribed camphene derivative, while compound 3 was a new natural product. Their structures and relative configurations were elucidated using HR-MS, NMR and ECD calculations. Compounds 1, 2, 5 significantly inhibited nitric oxide (NO) production in lipopolysaccharide (LPS)-induced RAW 264.7 cells, with IC50 values of 17.47±1.24, 14.92±1.17, and 30.48±1.48 μM, respectively.

Source: Records of Natural Products

DOI: 10.25135/rnp.542.2506.3558

Authors: Kai Feng, Han-Yue Liu, Yang Yu, Jin-Song Liu, Guo-Kai Wang, Yun-Peng Sun

Institution: Anhui University of Traditional Chinese Medicine

Language: English

Topic: Bioactive Natural Diterpenoids Research

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond

Funders: National Natural Science Foundation of China, Anhui University, State Administration of Traditional Chinese Medicine of the People's Republic of China, Anhui University of Chinese Medicine