In Vitro Assessment of the Effects of Endodontic Sealers on Cell Viability, Adhesion, and Migration
Year: 2025
Type: article
Abstract: This study aimed to evaluate the in vitro cytocompatibility and bioactivity of the newly launched calcium silicate-based sealer BioRoot Flow, compared with other calcium silicate-based sealers (AH Plus Bioceramic Sealer and BioRoot RCS) and the epoxy resin-based AH Plus Jet. NIH/3 T3 fibroblasts were used to assess cell viability, adhesion, and migration. Material characterisation was performed using SEM, EDS, and XRD. BioRoot RCS exhibited the highest cell viability, while BioRoot Flow showed fewer adherent cells and reduced migration at 72 h. EDS revealed zirconium content in BioRoot Flow, and XRD confirmed calcite presence in all calcium silicate-based sealers. Variations in cell behaviour may be related to differences in chemical composition and surface properties, highlighting the need for further investigation.
Source: Australian Endodontic Journal
DOI: 10.1111/aej.70013
Institution: Universidade Estadual de Campinas (UNICAMP)
Language: English
Subfield: Oral Surgery
Field: Dentistry
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $3,120
OpenAlex ID: W4413289656