Work

Porphyromonas gingivalis modulates E-cadherin expression: a mini-review of possible involved mechanisms

Year: 2025

Type: review

Abstract: Background Porphyromonas gingivalis ( P. gingivalis ), the bacterial strain responsible for pathogenic changes in periodontitis, can significantly deteriorate epithelial integrity, leading to its malfunction as a protective barrier against pathogens. As one of the known intercellular adhesive proteins, E-cadherin can be affected by P. gingivalis . Objectives This review summarizes the most recent research on the effect of this bacterium on E-cadherin, the suggested involved mechanisms, and the contribution of this protein deterioration in the systemic disease associated with periodontitis. Methods In September 2024, a comprehensive search was conducted using PubMed, Scopus, Web of Science, and Google Scholar. The search focused on articles published within the last five years. Review and non-English articles were excluded. Out of 83 records found in databases, 10 records were selected for this study. Results and Conclusion Most recent studies have consistently demonstrated the downregulation of E-cadherin in P. gingivalis -infected cells and tissues. However, there remains a need to elucidate the contribution of the bacterial infection and E-cadherin downregulation that occur during systemic diseases related to periodontitis, such as Epithelial-Mesenchymal Transition in cancer development.

Source: Medicine in Microecology

DOI: 10.1016/j.medmic.2025.100146

Authors: Zahra Khorshidi Asl, Mahtab Mottaghi, Fatemeh Farshad, Faezeh Azmoudeh

Institutions: Mashhad University of Medical Sciences, Tehran University of Medical Sciences, Qazvin University of Medical Sciences

Language: English

Topic: Oral microbiology and periodontitis research

Subfield: Periodontics

Field: Dentistry

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,670