Computational Analysis of the Role of Epigenetics in Insomnia:A Higher-Order Adaptive Network Model
Year: 2025
Type: article
Abstract: Insomnia Disorder (ID) is a prevalent stress-related sleep disorder involving burdening symptoms related to emotional disturbances. This paper introduces a higher-order adaptive dynamical system model to explore the potential role of epigenetic mechanisms in the development and persistence of ID. The model examines how epigenetic modifications, particularly in genes related to mechanisms of the sleep-wake regulation and stress response systems, may potentially contribute to the pathology of ID. Results of simulations of the model are reported in this study to underscore the complexity of ID as a dynamic and (mal-)adaptive system of emotion regulation and sleep-wake-regulation processes.
Authors: Jan Treur, Sarah Hassouna, Sophie CF Hendrikse
Institutions: Vrije Universiteit Amsterdam, Tilburg University
Language: English
Topic: Sleep and related disorders
Subfield: Experimental and Cognitive Psychology
Field: Psychology
Domain: Social Sciences
Open Access status: bronze
OpenAlex ID: W4413296101