Correlation Between Tissue EGFR Mutations and Telomerase Activity in Tissue and Blood of Patients with Lung Cancer: Immunohistochemical and Molecular Study
Year: 2025
Type: article
Study design: Observational Study
Abstract: Background: Lung cancer remains one of the leading causes of cancer-related mortality worldwide. Non-small cell lung cancer (NSCLC) accounts for approximately 85% of lung cancer. Epidermal growth factor receptor (EGFR) mutations are known to drive tumor progression, while telomerase activity is a key mechanism in cancer cell immortality. Objective: This study aims to investigate the correlation between EGFR mutations and telomerase activity in the blood of patients with lung cancer. Methods: This study aims to investigate the correlation between EGFR mutations and telomerase activity in blood and tissue of patients with lung cancer. A cohort study was analyzed for EGFR mutations in tissue and telomerase activity levels in blood using molecular techniques such as polymerase chain reaction (PCR) and in tissue biopsy by using telomerase immunohistochemistry (IHC). Results: The findings suggest a significant correlation between specific EGFR mutations in tissue and increased telomerase activity in blood. Conclusions: This study provides insights into tumor prognosis, response to therapy, and the detection of tumor development.
Authors: Fadhil Hussam Ahmed, Maan Hamad Al-Kalisy
Institution: University of Baghdad
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4413297243