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When Psychosis Meets Ptosis: A General Practice and Multidisciplinary Approach to Recognising Mitochondrial Neurogastrointestinal Encephalopathy

Year: 2025

Type: article

Abstract: When mental health issues coexist with seemingly unconnected physical conditions, the diagnosis process can become extremely complicated, necessitating a multidisciplinary approach and heightened clinical awareness. Mitochondrial neurogastrointestinal encephalopathy is an uncommon but significant example of a condition where mild neurological and gastrointestinal symptoms may appear and possibly conceal underlying metabolic abnormalities. With an emphasis on psychiatric, neurological and gastrointestinal symptoms that could complicate diagnosis, this featured review investigates how general practitioners (GPs) and multidisciplinary teams (MDTs) can identify atypical presentations of MNGIE. We emphasize the importance of general care in negotiating the intricacies of these uncommon multisystemic illnesses, as well as clinical hints and diagnostic techniques.

Source: SAS Journal of Medicine

DOI: 10.36347/sasjm.2025.v11i08.007

Authors: Dr Mohammad Mazharuddin, Dr Fathi Moustafa Abdalla Eid

Institution: Primary Health Care

Language: English

Topic: Mitochondrial Function and Pathology

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4413305143

FWCI:

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Related to: 10