Work

The potential role of daptomycin and quinupristindalfopristin as a bactericidal agent in the treatment of methicillin-resistant Staphylococcus aureus bacteremia

Year: 2025

Type: article

Abstract: Objectives: Methicillin-resistant Staphylococcus aureus (MRSA) bacteremia presents considerable clinical problems owing to elevated morbidity, mortality, and antibiotic resistance. This study evaluates the bactericidal efficacy of daptomycin and quinupristin-dalfopristin as potential treatments for MRSA bacteremia. Materials and Methods: This observational study, conducted from September 2017 to March 2018 at a tertiary care referral center in Northern India, analyzed 75 blood isolates of S. aureus. The Kirby–Bauer disc diffusion method and minimum inhibitory concentration testing were used to evaluate antimicrobial susceptibility by the Clinical and Laboratory Standards Institute 2017 standards. A statistical analysis compared the resistance patterns of MRSA and MRSA. Statistical analysis: The results showed that MRSA was much more resistant to aminoglycosides, fluoroquinolones, macrolides, and lincosamides than methicillin-susceptible S. aureus (MSSA), accounting for 70.66% of isolates (P < 0.05). Results: All isolates were completely susceptible to daptomycin; however, MRSA was more resistant to quinupristin-dalfopristin (69.81%) than MSSA (18.18%) (P = 0.00004). Conclusions: The results show that daptomycin is a safer and more effective treatment for MRSA bacteremia, but quinupristin-dalfopristin is still a good option in some situations, even though its resistance rates are higher. The research emphasizes the necessity for customized antimicrobial approaches, continuous monitoring, and combination therapy to address multidrug-resistant MRSA. Quinupristin-dalfopristin may be considered in refractory infections; however, daptomycin is the recommended treatment due to its persistent effectiveness against MRSA. Strategic antibiotic stewardship and novel therapy strategies are essential for enhancing outcomes.

Source: Journal of Laboratory Physicians

DOI: 10.25259/jlp_39_2025

Authors: Rani Kumari Jaiswal, Anuragani Verma, Vimala Venkatesh, Aditi Garg, Ankita Tripathi

Institution: King George's Medical University

Language: English

Topic: Antimicrobial Resistance in Staphylococcus

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $200