Work

Association of renal cortical thickness and renal function in patients with malignant hypertension with thrombotic microangiopathy: a biopsy-based cohort study from China

Year: 2025

Type: article

Abstract: Background Malignant hypertension (mHTN) is an acute form of hypertension with multiorgan damage, including renal impairment. Renal cortical thickness (RCT) by ultrasonography is associated with renal function in kidney disease. However, the relationship between RCT and renal dysfunction in mHTN is not yet fully understood. Design A cohort study. Setting This was a study conducted between January 2008 and June 2023 at the First Affiliated Hospital of Sun Yat-sen University. Participants A total of 292 mHTN patients with thrombotic microangiopathy (TMA) who underwent renal biopsy were included in the study. Primary outcomes and measures Patient characteristics for RCT were examined using linear regression. The association between RCT and an increase in estimated glomerular filtration rate (eGFR) of ≥15% was analysed by Cox regression. RCT was analysed in two groups classified by median RCT. Results Overall, patients with larger RCT exhibited a lower global sclerosis ratio and a lower proportion of intravascular thrombosis. RCT was strongly positively correlated with mean kidney length (coefficient B 1.018; 95% CI 0.638 to 1.397; p <0.001), body mass index (BMI) (coefficient B 0.146; 95% CI 0.075 to 0.217; p <0.001) and negatively related to intravascular thrombosis (coefficient B −1.314; 95% CI −2.060 to −0.567; p =0.001) and tubular atrophy/interstitial fibrosis ratio (coefficient B −0.880; 95% CI −1.569 to −0.192; p =0.012). Moreover, larger RCTs had a better renal function improvement of ≥15% increase in eGFR in patients with mHTN with TMA (HR 1.745; 95% CI 1.012 to 3.009; p =0.045). Conclusions Smaller RCTs were correlated with a decline in renal function and deterioration of renal pathology. Furthermore, larger RCTs showed a better renal function improvement of ≥15% increase in eGFR in mHTN patients with TMA. RCT may be a predictive factor for renal damage in mHTN.

Source: BMJ Open

DOI: 10.1136/bmjopen-2024-096581