Modulation of retinal inflammation delays degeneration in a mouse model of geographic atrophy
Year: 2025
Type: article
Abstract: ABSTRACT The advanced form of AMD, geographic atrophy, is associated with increased RPE oxidative stress and chronic inflammation. Here we evaluated the effects of delivering an anti-inflammatory viral gene by an AAV-vector in a mouse model of geographic atrophy. We measured changes in retinal function, structure, and morphology over nine months with electroretinography, optical coherence tomography, and fundoscopy, respectively. In addition, we used retinal tissue to quantify changes in markers of inflammation by multiplex ELISA, RT-qPCR, and immunofluorescence staining. Our AAV significantly delayed the loss of retinal function and structure and decreased retinal inflammation compared to the control AAV treatment. Our results suggest that modulating retinal inflammation could significantly slow the progression of geographic atrophy.
Source: Scientific Reports
Authors: Raela B. Ridley, Brianna M. Tischner, Jieun Lee, Erin Walsh, Michael T. Massengill, Alfred S. Lewin, Cristhian J. Ildefonso
Institutions: University of Florida Health, University of Florida
Language: English
Subfield: Ophthalmology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,690
OpenAlex ID: W4413308965