Work

Systemic mRNA aggregates elicit immunologic reprogramming that unlocks anti-cancer immunity

Year: 2025

Type: editorial

Abstract: Successful cancer immunotherapy requires novel approaches that overcome intratumoral immunosuppression and peripheral tolerance. In a recent manuscript describing intravenously administered mRNA-loaded lipid particle aggregates (RNA-LPAs), we demonstrate the ability to reprogram both the tumor microenvironment and periphery enabling cancer-specific immunity simultaneously generated to compete against immunologically 'cold' malignancies like glioblastoma.

Source: Human Vaccines & Immunotherapeutics

DOI: 10.1080/21645515.2025.2543599

Authors: Hector R. Mendez-Gomez, John A. Ligon, Ashley P. Ghiaseddin, Elias J. Sayour

Institutions: University of Florida, University of Florida Health

Language: English

Topic: Immunotherapy and Immune Responses

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,175