Year: 2025
Type: preprint
Abstract: A scanning acoustic microscope (SAM) imaging system calculates the speed of sound (SOS) and attenuation of sound (AOS) through sections and plots the values for each area as a color dot on the screen to create histological images. Because the harder and more viscous tissue shows faster SOS and greater AOS, respectively, SAM can provide data on the elasticity and viscosity of tissues and lesions. Areas with greater SOS and AOS correspond to those with higher concentrations of collagen or other fibers. SAM offers the following benefits: (1) images are acquired in only a few minutes without staining, (2) repeated observations following the same section are possible, (3) the same slide as light microscopy (approximately 10 µm thick) is available with comparable high resolution, (4) digitized SOS and AOS data are statistically comparable among different lesions. This SAM imaging system provides comparable data about not only the mechanical structure but also the functional alterations of organs or lesions.
Author: Katsutoshi Miura
Institutions: Hamamatsu University, Hamamatsu University School of Medicine
Language: English
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4413314122