Work

Confounding diagnosis of metastatic disease on FDG PET/CT due to cosmetic liquid silicone administration in breasts and gluteal regions with silicone migration to labia majora

Year: 2025

Type: article

Abstract: Cosmetic liquid silicone injections can result in silicone-induced inflammation, chronic mastitis, migration to distant locations and lymphadenitis which can result in false positive nodal and distant metastases. This study demonstrates a patient with multifocal FDG-avid right breast malignancy with FDG-avid bilateral axillary, mediastinal and abdominopelvic lymph nodes. She also had extensive FDG-avid foci in the bilateral breasts and subcutaneous gluteal regions secondary to cosmetic silicone administration. There was migration of injected silicone via the inguinal ligaments into her bilateral labia majora. In patients with extensive silicone injections, contrast-enhanced MRI, FDG-PET/CT and FES-PET/CT may assist in follow up for malignancy recurrence as the standard mammogram, ultrasound and CT follow-up demonstrates limited detection of interval changes.

Source: Radiology Case Reports

DOI: 10.1016/j.radcr.2025.07.064

Authors: Ya Ruth Huo B, Reece Tso, Lily Shen, Robert Mansberg

Institutions: Nepean Hospital, The University of Sydney

Language: English

Topic: Breast Implant and Reconstruction

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $600