Work

When huffing and puffing Ca2+ goes global, breast cancer cells are unmoved

Year: 2025

Type: article

Abstract: In this issue, Militsin et al. (https://doi.org/10.1083/jcb.202411203) reveal how STIM1 and STIM2-beyond their typical role as ER Ca2+ sensors that activate Orai1-control IP3R-mediated Ca2+ dynamics, thereby regulating breast cancer cell migration and invasion.

Source: The Journal of Cell Biology

DOI: 10.1083/jcb.202507062

Authors: Woo Young Chung, Shmuel Muallem

Institutions: National Institutes of Health, National Institute of Dental and Craniofacial Research

Language: English

Topic: Ion Channels and Receptors

Subfield: Sensory Systems

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funder: National Institutes of Health