Work

Immunogenicity and safety of a rabies-based highly pathogenic influenza A virus H5 vaccine in cattle

Year: 2025

Type: article

Abstract: The circulation of highly pathogenic H5 influenza A viruses in cattle, other mammals, and wildlife threatens animal and human health. To address this, we vaccinated heifer-calves with a deactivated rabies-virus-based H5 vaccine, which was well-tolerated and elicited neutralizing antibodies against both clade-1 and clade-2.3.4.4b H5N1 viruses, comparable to naturally H5-infected and convalescing cows. The immune responses to the vaccine platform were durable for at least 200 days and unaffected by preexisting RABV immunity.

Source: npj Vaccines

DOI: 10.1038/s41541-025-01238-2

Authors: Nir Paran, Christoph Wirblich, Catherine Olal, Alessandro Tarquinio, Kimberly H. Lohmeyer, Drishya Kurup, Stacey Schultz-Cherry, Ismaila Shittu, Gregory C. Gray, Dennis A. Bente, Pia U. Olafson, Matthias J. Schnell

Institutions: Thomas Jefferson University, The University of Texas Medical Branch at Galveston, Agricultural Research Service, Knipling-Bushland U.S. Livestock Insects Research Laboratory, St. Jude Children's Research Hospital

Language: English

Topic: Influenza Virus Research Studies

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,890

Funders: Agricultural Research Service, Sealy Institute for Vaccine Sciences, University of Texas Medical Branch, National Cancer Institute

Awards: G13330543, G1504261857, G2766465774

OpenAlex ID: W4413315967

FWCI: 3.67

Cites: 26

Cited by: 6

Related to: 10