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Reperfusion stroke injury and brain atrophy: a penumbra of progressive cognitive decline

Year: 2025

Type: editorial

Abstract: Reperfusion therapy has revolutionized ischemic stroke management, yet its potential to induce secondary reperfusion brain injury (RBI) has emerged as a critical concern. This editorial explores the mechanistic links between RBI, subsequent brain atrophy, and progressive cognitive decline. Inflammation, oxidative stress, astrocytic activation, and disruption of the neurovascular unit are implicated in this pathological continuum. Drawing from current literature, we discuss the potential role of astrocytosis in amyloid-β dynamics and highlight the urgent need for biomarkers and neuroprotective strategies that extend beyond acute care. Understanding these interconnections may reshape long-term stroke management and guide future research toward mitigating post-stroke neurodegeneration.

Source: Annals of Medicine and Surgery

DOI: 10.1097/ms9.0000000000003735

Authors: Vishal Chavda, Olobatoke Tunde Ayomide, Creed M Stary, Bipin Chaurasia

Institutions: University of Lagos, Stanford Medicine, Stanford University, College of Medical Sciences

Language: English

Topic: Acute Ischemic Stroke Management

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,850

OpenAlex ID: W4413346407

Cites: 18

Cited by: 1

Related to: 10