Work

Semaglutide drives weight loss through cAMP-dependent mechanisms in GLP1R-expressing hindbrain neurons

Year: 2026

Type: article

Source: Nature Metabolism

DOI: 10.1038/s42255-026-01534-8

Authors: Claire Gao, Isabelle C. Geneve, Shakira Rodriguez-Gonzalez, Chia Li, Kaitlyn McElhern, Marc L. Reitman, Andrew Lutas, Michael J. Krashes

Institutions: National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases

Language: English

Topic: Regulation of Appetite and Obesity

Subfield: Endocrine and Autonomic Systems

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Institute of General Medical Sciences, National Institute of Diabetes and Digestive and Kidney Diseases

Awards: G3319824486, The role of Parabrachial nucleus and its inputs from Area prostrema in signaling Semaglutide-mediated weight loss and regulation of appetite, G6601228359, Probing neural circuits underlying satiety, Investigating appetite control by G protein-coupled receptors

OpenAlex ID: W4413348317

FWCI: 12.35

Cites: 118

Cited by: 5

Related to: 10