Temporal effects of sympathetic denervation on aortic remodeling and rupture in experimental abdominal aortic aneurysm
Year: 2025
Type: article
Abstract: This study reveals the temporal effects of sympathetic denervation on aneurysm stability in an experimental model of AAA. Using 3-D light sheet microscopy, we demonstrate that ruptured AAAs exhibit the highest sympathetic innervation. Although delayed denervation reduced rupture risk and improved survival, serial denervation altered vascular remodeling. These findings establish SNS modulation as a key regulator of aneurysm progression and highlight the importance of timing in potential therapeutic interventions.
Institution: Northwestern University
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Awards: G2720716747, G92069414
OpenAlex ID: W4413350790