Work

Palladium-Catalyzed Carbonylative Fluoroalkylation of 1,3-Enynes to Access Allenyl Primary Amides

Year: 2025

Type: article

Abstract: A palladium-catalyzed difunctional fluoroalkylative carbonylation of 1,3-enynes with fluoroalkyl halides and ammonium iodide has been developed, providing rapid access to fluoroalkylated allenyl primary amides with a broad substrate scope, high chemo- and regioselectivity, and good functional group tolerance.

Source: Organic Letters

DOI: 10.1021/acs.orglett.5c03213

Authors: Chang-Sheng Kuai, Ru-Han A, Zhi-Peng Bao, Xiao-Feng Wu

Institutions: Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian National Laboratory for Clean Energy, University of Chinese Academy of Sciences, Leibniz Institute for Catalysis

Language: English

Topic: Fluorine in Organic Chemistry

Subfield: Pharmaceutical Science

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

Open Access status: hybrid

Estimated APC paid: $4,500

Funders: Dalian Institute of Chemical Physics, National Key Research and Development Program of China