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A New Lignan with Potential Anti-inflammatory Activity from Notopterygium incisum

Year: 2025

Type: article

Abstract: Notopterygium incisum is widely used in clinical practice because of its complex chemical composition and remarkable pharmacological effects. In this study, a previously undescribed lignan (1) was isolated from N. incisum. Its structure was evaluated through examinations of the NMR, HREIMS data and ECD calculation. Compound 1 demonstrated significant anti-inflammatory potential by inhibiting the secretion of nitric oxide (NO) in lipopolysaccharide (LPS)-induced macrophages, with an IC50 value of 3.57 μM.

Source: Records of Natural Products

DOI: 10.25135/rnp.2505.3518

Authors: Li-Lian Zhao, Su Hu, Xin-Yu Li, Yun Deng, Li Huang, Da-Le Guo

Institutions: Chengdu University of Traditional Chinese Medicine, Chengdu University

Language: English

Topic: Plant-derived Lignans Synthesis and Bioactivity

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond

Funder: National Natural Science Foundation of China