Clinical outcomes of gastroenteropancreatic neuroendocrine neoplasms in Taiwan: A multicenter registry study—TCOG T1214 study
Year: 2025
Type: article
Study design: Observational Study
Abstract: BACKGROUND: Gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) account for more than 50% of all NENs. The survival of patients with GEP-NENs has improved based on early diagnosis and improved treatment strategies. The real-world data of GEP-NENs in Taiwan are limited. A multicenter registry study was conducted to obtain real-world data on GEP-NENs in Taiwan. METHODS: Patients with pathologically diagnosed GEP-NENs were enrolled. Data were on the baseline characteristics, treatment strategies, and patient survival. Also evaluated was the expression status of six biomarkers, including SSTR2, SSTR5, PDX-1, CDX-2, mASH1, and NeuroD, in tumors. Overall survival (OS) was analyzed and plotted via the Kaplan-Meier method. Cox regression analysis was used to analyze the prognostic factors of OS. RESULTS: A total of 600 GEP-NEN patients were enrolled. Pancreatic NENs accounted for 43.0% of all patients. The 5-year and 10-year OS rates of all patients were 70.9% and 61.3%, respectively. In the multivariable Cox regression analysis, older age (hazard ratio [HR] = 1.02; 95% CI, 1.01-1.03), higher Eastern Cooperative Oncology Group performance status score, higher tumor grade (World Health Organization classification) and stage 4 disease (HR = 6.22; 95% CI, 3.60-10.76) were associated with poor OS. Positive SSTR2 expression (HR = 0.53; 95% CI, 0.31-0.91) was associated with better OS according to multivariate Cox regression analysis. CONCLUSIONS: This study provides real-world data on 600 GEP-NENs in Taiwan and identifies age, Eastern Cooperative Oncology Group performance status score, tumor grade, tumor stage, and SSTR2 expression as prognostic factors for the survival of GEP-NENs.
Source: Cancer
DOI: 10.1002/cncr.70019
Authors: Hui‐Jen Tsai, Ming‐Huang Chen, Hsiu‐Po Wang, Chin‐Fu Hsiao, Yen‐Yang Chen, Jen‐Shi Chen, Mei‐Due Yang, Chin‐Yuan Tzen, Yan‐Shen Shan, Li‐Yaun Bai, De‐Chuan Chan, Pei‐Yi Chu, Ching‐Liang Ho, Youngsen Yang, Johnson Lin, Hsuan‐Yu Lin, Cheng‐Shyong Chang, Chuan‐Cheng Wang, Tsann‐Long Hwang, Li‐Tzong Chen
Institutions: Kaohsiung Medical University, National Health Research Institutes, Kaohsiung Medical University Chung-Ho Memorial Hospital, National Cheng Kung University Hospital, National Cheng Kung University, Taipei Veterans General Hospital, National Taiwan University, National Taiwan University Hospital, Chang Gung University, Kaohsiung Chang Gung Memorial Hospital, Linkou Chang Gung Memorial Hospital, China Medical University, China Medical University Hospital, Tri-Service General Hospital, National Defense Medical Center, National Chung Hsing University, Chang Bing Show Chwan Memorial Hospital, Taipei Tzu Chi Hospital, Taichung Veterans General Hospital, Mackay Memorial Hospital, Changhua Christian Hospital, Chang Gung Memorial Hospital
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $4,790
OpenAlex ID: W4413356287