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Palladium-Catalyzed Monoarylation of Cyclopropylamine

Year: 2025
Type: article
Abstract: A novel palladium-catalyzed protocol for the monoarylation of cyclopropylamine using the sterically demanding and electron-rich adamantyl-substituted ylide-functionalized phosphine (YPhos) adYPhos is reported. This method enables the efficient coupling of a wide range of (hetero)aryl chlorides at room temperature. The reported ligand enhances the scope for the application of YPhos ligands in amination reactions on more challenging substrates. The protocol is versatile, accommodating various functional groups and extending to larger cycloalkylamines, all accessible under feasible and mild conditions.
DOI: 10.1021/acs.joc.5c01233
Language: English
Field: Chemistry
Open Access status: hybrid
Estimated APC paid: $4,500
Funders: Verband der Chemischen Industrie, Fonds der Chemischen Industrie, European Commission, Deutsche Forschungsgemeinschaft, European Research Council, HORIZON EUROPE European Research Council
Awards: EXC 2033: RESOLV (Ruhr Explores Solvation), G1950985831, G199205490, G274347230, G3334287513, G4211023474, HPLCKopplung mit Gelpermeationschromatographie, G649001848, Carbanions as Functional Groups and Building Blocks for Novel Reagents, Catalysts and Materials
OpenAlex ID: W4413357302
FWCI: 0.581
Cites: 71
Cited by: 2
Related to: 10