Work

Bezafibrate improves mitochondrial function, blood-brain barrier integrity, and social deficits in models of 22q11.2 deletion syndrome

Year: 2025

Type: article

Source: Science Translational Medicine

DOI: 10.1126/scitranslmed.ads2116

Authors: Alexis M. Crockett, Maria C. Vélez Colόn, Hanna Kebir, Frances M. Smith, Daniel M. Iascone, Brianna Ciesielski, Sergei Koshkin, Andrew D. Patterson, Adam J. Rossano, Amita Sehgal, Stewart A. Anderson, Jorge Ivan Alvarez

Institutions: University of Pennsylvania, Children's Hospital of Philadelphia, Pennsylvania State University, Howard Hughes Medical Institute

Language: English

Topic: Barrier Structure and Function Studies

Subfield: Neurology

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: closed

Funders: National Institutes of Health, National Institute of Mental Health, National Institute of Neurological Disorders and Stroke, National Center for Advancing Translational Sciences, Eunice Kennedy Shriver National Institute of Child Health and Human Development

Awards: G1062989364, Generating and accelerating the maturation of Pvalb-fast spiking interneurons from human stem cells, IPSC phenotype, mitochondrial haplotype and psychosis in 22q11 deletion syndrome, G4508964350, G471519714, G5312160427, Cycling in a circadian circuit, The Intellectual and Developmental Disabilities Research Center (IDDRC) at CHOP/Penn, Institutional Clinical and Translational Science Award

OpenAlex ID: W4413362591

FWCI: 2.65

Cites: 107

Cited by: 9

Related to: 10