Get started
Work

Cluster analysis of hotspots and research trends of epirubicin-induced cardiotoxicity: a bibliometric study

Year: 2025
Type: article
Abstract: Background: Epirubicin, a widely used anthracycline, effectively treats various cancers but poses a high risk of cardiotoxicity, leading to heart failure and myocardial dysfunction. This study conducts a cluster analysis to map global research trends in epirubicin-induced cardiotoxicity. Methods: A literature search was conducted using the Web of Science Core Collection database. Bibliometric tools, including VOSviewer, CiteSpace, and R package "bibliometrix", were employed. Results: P.F. Conte, J.W. Hopewell, and B. Salvadori were the most influential authors. Cluster analysis identified four research hotspots: mechanisms of cardiotoxicity, clinical applications of chemotherapy regimens, combination therapies and pharmacokinetics, formulation advancements and cardioprotective strategies. In addition, there is a clear cut-off among the strongest citation bursts, with the period from 2004-2013 primarily concentrated on disease treatment. From 2014 onwards, the last 10 years have focused on cardiotoxicity and the underlying mechanisms of cardiotoxicity. Conclusion: This bibliometric study, based on cluster analysis, identified four research hotspots including mechanisms of cardiotoxicity, clinical applications of chemotherapy regimens, combination therapies and pharmacokinetics, formulation advancements and cardioprotective strategies. Future research directions should prioritize the development of AI-driven risk prediction models, integration of multi-omics biomarkers into clinical workflows, and establishment of international cardio-oncology consortiums to enhance personalized cardioprotective strategies and optimize patient outcomes.
DOI: 10.3389/fphar.2025.1616162
Language: English
Field: Medicine
Open Access status: gold
Estimated APC paid: $3,801
OpenAlex ID: W4413362791
FWCI: 2.519
Cites: 39
Cited by: 4
Related to: 10