Severe Acute Kidney Injury Associated With Intestinal Ostomies
Year: 2025
Type: article
Study design: Observational Study
Abstract: Rationale & Objective: People with ostomies can experience high output, a risk of acute kidney injury (AKI). We evaluated patients with AKI associated with ostomies (ostomy-AKI) and compared with AKI of other etiologies (general-AKI) with the objective of describing their clinical presentation and their association with major adverse kidney events at 10 and 30-90 days (major adverse kidney events [MAKE] 10 and 30-90, respectively). Study Design: A retrospective cohort study. Setting & Participants: Conducted at the Hospital Civil of Guadalajara. We included patients with Ostomy-AKI and General-AKI. Exposures or Predictors: Ostomy-AKI. Outcomes: Describing and differentiating their clinical presentation and their association with MAKE 10 and MAKE 30-90, in addition to its individual components, as death, new requirement for dialysis, or ≥25% decline in the estimated glomerular filtration rate from baseline. Analytical Approach: Analyzed the risk by logistic regression model and a multivariate Cox proportional hazard. Results: = 0.01, respectively). Limitations: A retrospective cohort, residual confounding, and small sample size. Conclusions: In comparison with general-AKI, patients with ostomy-AKI present more often with hypovolemia and greater AKI stage, had a higher mortality at 30-90 day follow-up, and a 2.5-fold increase in risk of MAKE.
Source: Kidney Medicine
Authors: Juan A. Gómez-Fregoso, Jose J. Zaragoza, Juan Alberto González-Duarte, Carlos M. Nuño-Guzmán, Eduardo M. Hernández-Barajas, Zarahi Andrade-Jorge, Juarez Correa-de Leon, Jorge L. Padilla-Armas, Rebeca Lizzete Ornelas-Ruvalcaba, José Said Cabrera-Aguilar, Gael Chávez-Alonso, Estefania Villalvazo-Maciel, Carlos E. Orozco-Chan, Gonzalo Rodríguez-García, Guillermo Navarro-Blackaller, Ramón Medina-González, Alejandro Martínez Gallardo-González, Luz Alcantar-Vallin, Gabriela J. Abundis-Mora, Guillermo García-García, Jonathan S. Chávez-Iñiguez
Institutions: Universidad de Guadalajara, Hospital Civil de Guadalajara
Language: English
Topic: Acute Kidney Injury Research
Subfield: Nephrology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,590
Funder: Secretaría de Salud
OpenAlex ID: W4413363667