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Case Report: Rhabdomyolysis following initiation of tirzepatide

Year: 2025

Type: article

Abstract: We present the case of a 66-year-old woman who developed weakness, nausea, and vomiting accompanied by markedly elevated creatine kinase levels after first treatment with an increased dose of tirzepatide. Laboratory findings were consistent with rhabdomyolysis and normalized within 4 days following discontinuation of tirzepatide and initiation of supportive intravenous fluid therapy. The temporal relationship strongly suggests tirzepatide as a likely trigger. Off-label use, particularly for weight loss, should be avoided and approached with caution. To the best of our knowledge, this is the first reported case of rhabdomyolysis following the initial administration of tirzepatide.

Source: Frontiers in Pharmacology

DOI: 10.3389/fphar.2025.1660785

Authors: Jonas Michael Bodanowitz, Isabell Mattes, Micha Loebermann, Carlos Fritzsche

Institutions: Universitätsmedizin Rostock, University of Rostock

Language: English

Topic: Muscle and Compartmental Disorders

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,801