Effect of ketamine on cellular immunity and inflammation in patients who undergo laparoscopic colon cancer surgery: a retrospective study
Year: 2025
Type: article
Study design: Observational Study
Abstract: Objective Anesthesia during the surgery impairs immune systems. Ketamine is an anesthetic with immune protective effects. This study intended to investigate the effect of a ketamine-involved anesthetic regimen on cellular immunity and inflammatory cytokines in patients who undergo laparoscopic colon cancer surgery. Methods This retrospective study screened 60 patients who underwent laparoscopic colon cancer surgery with an anesthesia regimen involving ketamine (N = 30, ketamine group) or not (N = 30, opioid group). Data on surgery-related parameters, blood pressure, heart rate (HR), blood routine examination parameters, cluster of differentiation (CD) 3+ and CD4+ T cells, inflammatory cytokines, and adverse reactions were retrieved. Time points were defined as entering the operating room (T1), 5 min after anesthetic induction (T2), the end of surgery (T3), and 24 h after surgery (T4). Results The 1 h-postoperative pain score (P < 0.001) and length of stay (P < 0.001) were lower in ketamine group than in opioid group. Blood pressure and HR from T1 to T4 were more stable in ketamine group than in opioid group. Neutrophils (P < 0.001), CD3+ (P < 0.001) and CD4+ T cells (P = 0.002) at T4 were higher in ketamine group than in opioid group. Interleukin (IL)-10 at T3 (P < 0.001) and T4 (P < 0.001) were higher, while IL-6 at T3 (P < 0.001) and T4 (P < 0.001) were lower in ketamine group than in opioid group. There was no discrepancy in incidences of adverse reactions between groups. Conclusion A ketamine-involved anesthetic regimen seems to be correlated with the improvement of cellular immunity and inflammation with a tolerable safety profile. However, more studies with a prospective, randomized, controlled design are needed to verify this finding and draw a solid conclusion.
Source: Frontiers in Pharmacology
Authors: Jiajia Ji, Haiping Zhang, Lixia Zhou, Chunlan Fan, Ligen Dai, Shaolei Mao
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,801
OpenAlex ID: W4413368266