Work

Front Cover: Inhibition of the Clathrin Terminal Domain—Amphiphysin Protein–Protein Interaction. Probing the Pitstop 2 Aromatic Moiety (ChemMedChem 16/2025)

Year: 2025

Type: paratext

Abstract: This image shows the crystal structure of the N-terminal domain of clathrin with the known binding sites colored. Site 1 is colored in yellow, and an expansion shows a stylized image of the predicted binding of a Pitstop 2 analogue compared to Pitstop 2 in binding site. The background shows a selection of the Pitstop 2 analogues described in the article in various colors. More details can be found in research article 10.1002/cmdc.202500321 by Adam McCluskey and co-workers.

Source: ChemMedChem

DOI: 10.1002/cmdc.70019

Authors: Kate Prichard, Mark J Robertson, Ngoc Chau, Jing Xue, Martin Neuenschwander, Uwe Fink, Andre Horatscheck, Marc Nazare, Phillip J Robinson, Volker Haucke, Adam McCluskey

Institutions: University of Newcastle Australia, The University of Sydney, Children's Medical Research Institute, Leibniz-Forschungsinstitut für Molekulare Pharmakologie

Language: English

Topic: Cellular transport and secretion

Subfield: Cell Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: bronze

OpenAlex ID: W4413369134

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