The association between the Charlson Comorbidity Index and prognosis in patients with supratentorial spontaneous intracerebral hemorrhage following hematoma evacuation
Year: 2025
Type: article
Study design: Observational Study
Abstract: Background: Spontaneous intracerebral hemorrhage (ICH) carries high mortality and morbidity. Compared to deep ICH, acute lobar ICH has distinct profiles and poorer early prognosis, frequently associated with non-hypertensive etiologies. The Charlson Comorbidity Index (CCI) is linked to critical ICH outcomes. This study assessed the relationship between CCI and prognosis following hematoma evacuation in supratentorial spontaneous ICH patients. Methods: Three hundred and eighty-one patients with spontaneous supratentorial ICH underwent hematoma evacuation, with their CCI scores categorized into low and high comorbidity groups. Following an analysis of demographic data, medical history, clinical and imaging characteristics, and poor outcomes [modified Rankin Scale (mRS) 4-6], the study examined the differences in CCI between the two groups. Logistic regression analysis was conducted to assess the correlation between CCI and the poor outcomes in patients with supratentorial ICH after hematoma evacuation. Results: 37 (90.2%), P<0.001] was also higher in the High comorbidity group. According to logistic regression analysis, a high CCI score was independently associated with poor outcomes in Model 1 [Model 1, odds ratio (OR) 5.80; 95% confidence interval (CI): 2.02-16.64; P=0.001]. After adjusting for clinical preset variables in Model 2, the difference remained statistically significant (Model 2, OR 7.48; 95% CI: 2.15-25.96; P=0.002). After adjusting for baseline differences and clinical preset variables, the results remained consistent (Model 3, OR 10.68; 95% CI: 2.76-41.30; P<0.001; Model 4, OR 10.89; 95% CI: 2.75-43.05; P<0.001). Conclusions: In patients with supratentorial ICH post-evacuation, a higher CCI score correlates with poorer prognosis. The high CCI group has a ninefold increased risk of unfavorable outcomes, which guides clinical treatment and prognostic assessment.
Authors: Qiangjun Wu, Huirong Xie, Hao Chen, Jingping Sun, Bailong Xin
Institutions: Lishui Central Hospital, Wenzhou Medical University
Language: English
Subfield: Neurology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4413369435