Reduced pulmonary vascular bed volume in cryptogenic stroke patients with patent foramen ovale: a myocardial contrast echocardiography study
Year: 2025
Type: article
Study design: Observational Study
Abstract: Background: Pulmonary vascular bed volume (PVBV) in cryptogenic stroke patients with patent foramen ovale (PFO) has not been well characterized. This study examined PVBV in cryptogenic stroke patients with suspected PFO. Methods: A total of 469 patients underwent agitated saline contrast transthoracic echocardiography (TTE) and transesophageal echocardiography (TEE) between January 2021 and December 2024. PVBV was quantified by myocardial contrast echocardiography (MCE). Results: =0.447, P<0.0001). The model effectively predicted PVBV below 250 mL, with an area under the receiver operating characteristic curve (AUC) of 0.811 (sensitivity, 77.2%; specificity, 86.2%). For PVBV below 200 mL, the AUC improved to 0.881 (sensitivity, 100%; specificity, 73.9%). Conclusions: PVBV is reduced in cryptogenic stroke patients with PFO, and right-to-left shunt level, BSA, and gender were the factors associated with PVBV. Addressing these gaps could enhance the understanding of cardiopulmonary interactions in PFO.
Authors: Li Xu, Jie Zhang, Donghua Wang, Yanli Lv, Xiaozhi Zheng
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4413369442