[Research progress in auxiliary components of nerve conduit for treating peripheral nerve injuries].
Year: 2025
Type: article
Abstract: Objective: To review recent research progress in the use of auxiliary components of nerve conduits for the treatment of peripheral nerve injuries. Methods: An extensive review of recent domestic and international literature was conducted to evaluate the role of auxiliary components in nerve conduits for peripheral nerve repair, with a focus on their effects and underlying mechanisms. Results: By incorporating auxiliary components such as bioactive molecules, therapeutic cells, and their derivatives, nerve conduits can create a more biomimetic regenerative microenvironment. This is achieved by providing neurotrophic support, modulating the immune microenvironment, improving blood and oxygen supply, and offering directional guidance for nerve regeneration. Consequently, the nerve conduit is transformed from a simple physical scaffold into an active, bio-functional repair system, which enhances the effectiveness for PNI. Conclusion: experiments. Randomized controlled clinical trials are necessary to validate their clinical effectiveness.
Source: PubMed
Authors: Chaocao Nong, Haodong Lin
Institution: Shanghai Jiao Tong University
Language: English
Subfield: Cellular and Molecular Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W4413369590