Figure 6 from Direct Co-Targeting of Bcl-xL and Mcl-1 Exhibits Synergistic Effects in AR-V7–Expressing CRPC Models
Year: 2025
Type: other
Abstract: XZ739 in combination with S63845 has synergistic antitumor effects in CRPC cell lines. A to I, CellTiter-Glo viability data from 2D cultures of LNCaP95, VCaP-CR, and 22Rv1 cell lines. Cell viability data for the dual treatment (A–C) were generated by CellTiter-Glo. Dose–response matrices (D–F) and Bliss synergy plots (G–I) were created using the SynergyFinder+ R package. J to M, 3D spheroid model and cell viability of LNCaP95 (J and K) and 22Rv1 cells (L and M). Data are presented as mean ± SD. **, P < 0.01; ****, P < 0.0001. All experiments were completed in triplicate. Spheroid images are representative of three replicates.
Authors: Benjamin C. Brim, Andres F. Leon, Erica L. Beatson, Jessica D. Kindrick, Kinjal Bhadresha, Xiaohu Zhang, Giulia C. Napoli, Emily N. Risdon, Keith T. Schmidt, Kelli M. Wilson, Crystal McKnight, Erin Beck, Carleen Klumpp-Thomas, Michele Ceribelli, JuanJuan Yin, Adam G. Sowalsky, Douglas K. Price, Cindy H. Chau, Craig J. Thomas, William D. Figg
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4413369902