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DNA Repair Pathways in Carcinogenesis: Mechanisms, Modulation, and Future Directions for Cancer Prevention

Year: 2025

Type: article

Abstract: DNA repair mechanisms are prime custodians of genomic integrity and their deregulation is essentially a central feature during oncogenesis. This study surveys the molecular pathways of micro base excision repair (BER), nucleotide excision repair (NER), mismatch repair (MMR), and dual strand repair (DSBR) through homologous recombination (HR) and by no means homologous end joining (NHEJ), and this is by particular attention to the way that they take part in carcinogenic adjustment. Clinical data show that germline BRCA1/2, MLH1, and MSH2 mutations systems cause susceptibility to hereditary cancer, and somatic variants of the repair genes promote tumorigenesis. Further, the epigenetic silencing of the repair capacity as well as oxidative stress and oncogenic signal transduction pathways also play a role in the chemoresistance and the development of the disease. Existing treatment approaches, such as PARP inhibitors and immune checkpoint manipulation are specific modalities, in addition to synthetic lethality approaches, assessed within this study as interventional and preventative measures. Education on repair pathway control can guide the precise oncology, early indication makers, translation of the oncology prevention method, which in turn can control morbidity and enhance the prognosis of the patient

Source: Journal of Carcinogenesis

DOI: 10.64149/j.carcinog.24.2.102-109

Authors: Suleiman Ibrahim Mohammad, Hanan Jadallah, Asokan Vasudevan

Institutions: INTI International University, Zarqa University, Shinawatra University

Language: English

Topic: DNA Repair Mechanisms

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,500