Figure 4 from Direct Co-Targeting of Bcl-xL and Mcl-1 Exhibits Synergistic Effects in AR-V7–Expressing CRPC Models
Year: 2025
Type: other
Abstract: Live-cell imaging reveals dynamics of apoptosis and proliferation dynamics after dual treatment of A-1331852 and S63845. A to C, Count of cells with notable caspase 3/7 cleavage measured by a green fluorescent signal after dual treatment. D to F, Proliferation of cells after dual treatment as measured by the confluency of each well. All experiments contained three biological and three technical replicates. Data are plotted as mean ± SD of the means from each experiment.
Authors: Benjamin C. Brim, Andres F. Leon, Erica L. Beatson, Jessica D. Kindrick, Kinjal Bhadresha, Xiaohu Zhang, Giulia C. Napoli, Emily N. Risdon, Keith T. Schmidt, Kelli M. Wilson, Crystal McKnight, Erin Beck, Carleen Klumpp-Thomas, Michele Ceribelli, JuanJuan Yin, Adam G. Sowalsky, Douglas K. Price, Cindy H. Chau, Craig J. Thomas, William D. Figg
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
OpenAlex ID: W4413370202