Figure 2 from Direct Co-Targeting of Bcl-xL and Mcl-1 Exhibits Synergistic Effects in AR-V7–Expressing CRPC Models
Year: 2025
Type: other
Abstract: Co-targeting Mcl-1 and Bcl-xL enhances the inhibitory effect on cell viability. The effect on cell viability of A-1331852 (targeting Bcl-xL) in combination with S63845 (targeting Mcl-1; A–C) and navitoclax (targeting Bcl-xL and Bcl-2) in combination with S63845 (D–F). Cell viability was determined following either 48-hour (22Rv1 and LNCaP-95) or 72-hour treatment (VCaP-CR) by CellTiter-Glo luminescent assay. The data provided represent the mean ± SD from three independent experiments with at least three technical replicates per experiment.
Authors: Benjamin C. Brim, Andres F. Leon, Erica L. Beatson, Jessica D. Kindrick, Kinjal Bhadresha, Xiaohu Zhang, Giulia C. Napoli, Emily N. Risdon, Keith T. Schmidt, Kelli M. Wilson, Crystal McKnight, Erin Beck, Carleen Klumpp-Thomas, Michele Ceribelli, JuanJuan Yin, Adam G. Sowalsky, Douglas K. Price, Cindy H. Chau, Craig J. Thomas, William D. Figg
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
OpenAlex ID: W4413370472