Work

5,7‐Membered Cyclometallated Gold(III) Complexes with Pyridine‐Phenyl‐Oxazoline N^C^N Ligands as Catalysts for Organic Transformation Reactions Under Silver‐Free Conditions

Year: 2025

Type: article

Abstract: A series of 5,7‐membered cyclometallated gold(III) complexes with N^C^N tridentate ligands are developed as catalysts, which are prepared via transmetalation of pyridine‐phenyl‐oxazoline ligand‐containing organomercury compounds with potassium gold(III) chloride (KAuCl 4 ) with up to 86% yields. Investigation on the synthesis and catalytic activity of the newly developed gold(III) complexes under silver‐free conditions results in >90% conversion for propargylamines and up to >99% conversion for bifunctional modification of oligosaccharides via three‐component (A 3 )‐coupling reactions. Employment of the tridentate gold(III) complexes also successfully catalyzes the carboalkoxylation reaction of acetal alkynes. These results reveal potential applications of such 5,7‐membered tridentate gold(III) complexes as catalysts for organic transformation reactions and modification of biomolecules.

Source: Advanced Synthesis & Catalysis

DOI: 10.1002/adsc.70038

Authors: Yosephine Tania Limanto, Karen Ka‐Yan Kung, Aries Kwok‐Heung Chan, Nathanael Chun‐Him Lai, Man‐Kin Wong

Institution: Hong Kong Polytechnic University

Language: English

Topic: Catalytic Alkyne Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $4,650

Funder: Hong Kong Polytechnic University