Gouty inflammation: genetic mechanisms towards flare therapy
Year: 2025
Type: article
Abstract: PURPOSE OF REVIEW: This review presents evidence for pathways that have genetic underpinnings in gout that should be prioritized for further study and therapeutic development. RECENT FINDINGS: Recent genome-wide association studies have identified molecular mechanisms in the pathogenesis of gout that converge on cell metabolism, phagocytosis of crystals and cytokine signalling. SUMMARY: Understanding how the gene pathways function to influence the gout flare; crystal formation, crystal deposition and the subsequent immune response and inflammation characteristic of the gout flare is critical to developing additional therapies in the gout repertoire.
Source: Current Opinion in Rheumatology
Authors: Daniel Lyth, Megan Leask
Institution: University of Otago
Language: English
Subfield: Nephrology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W4413373441