Year: 2025
Type: article
Abstract: The readily accessible iron complex [Cp*FeCl(tmeda)] is an effective catalyst for the highly regio‐ and stereoselective trans‐hydrostannylation of terminal alkyl alkynes, affording a type of alkenylstannanes that is difficult to make otherwise. The R3Sn‐ moiety is faithfully delivered to the terminal C‐atom, unless a propargylic or homo‐propargylic ─OH or ─NH2 group is present in the substrate, which (partly or fully) inverts the regiochemical course; this steering effect, however, can be switched off upon protection of the protic site. The trans‐addition likely starts by insertion of the [Cp*FeCl] fragment into the R3Sn─H bond, followed by a migratory insertion of the ligated alkyne into the Fe─Sn unit of the Fe(IV) species thus formed. This “modified Chalk–Harrod” mechanism is manifested in a stannylative cyclization of 1,6‐enyne derivatives, which has hardly any precedent either; a pathway via iron vinylidene intermediates can be excluded on the basis of deuterium labeling experiments.
Source: Angewandte Chemie
Authors: Soumyadeep Chakrabortty, Alois Fürstner
Institution: Max-Planck-Institut für Kohlenforschung
Language: English
Topic: Catalytic Alkyne Reactions
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: hybrid
Estimated APC paid: $5,790
Funder: Goddard Space Flight Center
OpenAlex ID: W4413373518