Work

Nonmechanical Small Bowel Obstruction in a Patient on Zepbound Without a Surgical History: A Case Report

Year: 2025

Type: article

Abstract: We present the case of a 52-year-old woman who developed a functional small bowel obstruction despite having no history of abdominal surgery, prior bowel obstruction, or GI interventions. The only notable recent change in her medical history was a dose escalation of Zepbound (tirzepatide), a glucagon-like peptide-1/glucose-dependent insulinotropic polypeptide agonist prescribed for weight loss. This case raises concern about potential severe GI motility complications associated with Zepbound, particularly in the absence of conventional SBO risk factors.

Source: Cureus

DOI: 10.7759/cureus.90657

Authors: Nicholas Lorenz, John Stauffer, Alex Abouafech, Amia Mourad, Kelvin Bray

Institutions: Lake Erie College of Osteopathic Medicine, Baptist Medical Center Beaches

Language: English

Topic: Pharmacology and Obesity Treatment

Subfield: Pharmacology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4413374599