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Multisite infection with Austrian syndrome caused by non-vaccine pneumococcal serotype—case report

Year: 2025

Type: article

Abstract: ABSTRACT Background Although rare, Austrian syndrome remains a life-threatening triad consisting of pneumonia, endocarditis, and meningitis caused by Streptococcus pneumoniae . Case Summary We present a case of Austrian syndrome, further complicated by spondylodiscitis and endophthalmitis, in an immunocompromised male receiving methotrexate treatment for rheumatoid arthritis. The infection was caused by a non-vaccine pneumococcal serotype (23B). Susceptibility testing showed reduced susceptibility towards benzylpenicillin, an uncommon finding in Denmark. Conclusion This case illustrates some of the challenges faced in managing invasive pneumococcal disease and underlines the importance of continued awareness of this disease, particularly in immunocompromised patients.

Source: ASM Case Reports

DOI: 10.1128/asmcr.00061-25

Authors: Frederik Juel Pontoppidan Børrild, Emil Fosbøl, Casper Roed, Melissa Hornbæk Øvre, Helle Brander Eriksen, Christian Kraef, Jannik Helweg-Larsen, Zitta Barrella Harboe, Christina Ekenberg

Institutions: Copenhagen University Hospital, Rigshospitalet, University of Copenhagen, Statens Serum Institut

Language: English

Topic: Pneumonia and Respiratory Infections

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W4413375079

FWCI: 0.623

Cites: 13

Cited by: 1

Related to: 10