Work

How to control synaptic autophagy from the neuronal soma

Year: 2025

Type: article

Abstract: Autophagy dysregulation at the neural synapse is a hallmark of Parkinson’s disease and has diverse molecular origins. New research in The EMBO Journal investigates the role of Drosophila Rab39, and uncovers a system for compartmentalized regulation of synaptic autophagy, with implications for our understanding of dysregulated synaptic proteostasis as observed in neurodegenerative diseases.

Source: The EMBO Journal

DOI: 10.1038/s44318-025-00535-9

Authors: Sheng Huang, Stephan J Sigrist

Institutions: NeuroCure Cluster of Excellence, Freie Universität Berlin, Charité - Universitätsmedizin Berlin

Language: English

Topic: Autophagy in Disease and Therapy

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $7,990