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Supplementary Fig. S1 from Mathematical Modeling and Association Analysis Decipher the Impact of the Gut Microbiome on Cancer Immunotherapy

Year: 2025

Type: supplementary-materials

Abstract: Schematic of the mathematical model of tumor-immune system interactions, highlighting key immune components, their activation and cytolytic functions, and modulation by PD-1/PD-L1 signaling. The model also incorporates cytokine effects and the influence of immunosuppressive cells like M2 macrophages and Tregs.

DOI: 10.1158/0008-5472.29918669

Authors: Andreas G. Hadjigeorgiou, Constantinos Harkos, Aditya K. Mishra, Golnaz Morad, Sarah B. Johnson, Nadim J. Ajami, Jennifer A. Wargo, Lance L. Munn, Triantafyllos Stylianopoulos, Rakesh K. Jain

Language: English

Topic: Cancer Immunotherapy and Biomarkers

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4413380339

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