Work

Effect of Netarsudil 0.02% on a Patient with Fuchs Corneal Dystrophy and Radial Keratotomy

Year: 2025

Type: article

Abstract: This study reports an unusual case of dramatic change in visual acuity, pachymetry, and corneal topography in a patient with a history of Fuchs dystrophy and radial keratotomy following the use of Rho-kinase (ROCK) inhibitor. A patient with a history of 8-cut radial keratotomy (RK), astigmatic keratotomy (AK), and Fuchs dystrophy showed dramatic changes in visual acuity, pachymetry, and corneal topography after using one drop of netarsudil 0.02%. The dramatic effect of netarsudil in our patient may be due to increased penetration of a rho-kinase inhibitor from the corneal incisions, facilitating the effect on corneal endothelium, resulting in a dramatic improvement in corneal pachymetry. This suggests a potential role for corneal incisions to improve the effectiveness of rho-kinase inhibitors in patients with Fuchs dystrophy.

Source: Journal of Clinical & Translational Ophthalmology

DOI: 10.3390/jcto3030017

Authors: Praneetha Thulasi, Shae Chambers, Soroosh Behshad

Institutions: Washington University in St. Louis, Emory University, Emory Eye Center, University of California, Irvine

Language: English

Topic: Corneal surgery and disorders

Subfield: Radiology, Nuclear Medicine and Imaging

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,207