Work

Prostate-Specific Membrane Antigen Positron Emission Tomography-Detected Intrahepatic Cholangiocarcinoma in a Patient With Metastatic Castration-Resistant Prostate Cancer: Dual Cancer Management With Pluvicto and Intensity-Modulated Radiation Therapy

Year: 2025

Type: article

Abstract: Intrahepatic cholangiocarcinoma (ICC) is a rare hepatobiliary malignancy often diagnosed at advanced stages due to its silent progression. Prostate-specific membrane antigen (PSMA) PET/CT, primarily used in prostate cancer, can incidentally detect unrelated malignancies. In a patient with metastatic castration-resistant prostate cancer (mCRPC), PSMA PET/CT revealed a liver lesion initially presumed metastatic. However, lack of uptake on post-therapy single-photon emission computed tomography/CT (SPECT/CT) prompted further evaluation, and MRI with biopsy confirmed ICC. The patient received intensity-modulated radiation therapy (IMRT) for ICC, stereotactic body radiation therapy (SBRT) for prostate metastases, and continued Lu-177 PSMA-617 therapy. This case highlights the incidental diagnostic value of PSMA PET and the importance of post-therapy imaging and multidisciplinary care in managing complex cancer presentations.

Source: Cureus

DOI: 10.7759/cureus.90145

Authors: Harshad R Kulkarni, Kevin A Maupin, Emerson Lim, Eric P Buth, Brandon R Mancini

Institutions: Grand Rapids Public Library, Michigan State University, Corewell Health

Language: English

Topic: Cholangiocarcinoma and Gallbladder Cancer Studies

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4413381067