Work

In vitro mixing formulas for antimicrobial calcium sulfate beads for point-of-care applications: an additional update to formulas

Year: 2025

Type: article

Abstract: ) product to create small-sized beads (3-6 mm). Antimicrobial-loaded calcium sulfate (ALCS) beads are applied as surgeon-directed, point-of-care use in cases of periprosthetic joint infection (PJI), fracture-related infection (FRI), and other related bone site infections. This treatment technique has been utilized more frequently in the last decade to combat microbial musculoskeletal infections (MSIs). With the widening spectrum of identified microbes encountered in MSIs, we have provided additional antimicrobial formulas to be used singularly and in combination using our in vitro mixing lab protocol previously published. This communication reports 20 additional agents/combinations tested using our protocol to arrive at a standard mix formula or, when necessary, a modified mixing method. Most mixing formulas derived were for antimicrobials effective against fungi and mycobacterium species.

Source: Journal of Bone and Joint Infection

DOI: 10.5194/jbji-10-309-2025

Authors: Edward J. McPherson, Andrew J. Wassef, Matthew V. Dipane, Madhav Chowdhry

Institutions: University of California, Los Angeles, Aligarh Muslim University, University of Oxford

Language: English

Topic: Orthopedic Infections and Treatments

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,078